About Us
Based of over 6 years of research conducted at Unique, Geneva and Switzerland
Identified in vitro using phenotypically-driven screening based on proprietary Therapeutically Guided Multidrug Optimization (TGMO) technique
STEP 1
Dose -response curve for each compound to identify low dose
STEP 2
Testing drug combinations and data modeling
STEP 3
Elimination of antagonistic molecules
OUR TECHNOLGY
Overview of the streamlined s-FSC technique used for in vitro drug combination optimization showing the three search steps used. The procedure starts with the the first search where the interactions of the initial set of drugs were investigated by testing 91 drug combinations for cell viability inhibition. The result are analyzed using a second-order linear regression analysis that enables the elimination of the least significant compounds.
In the next step (Search 2.1) the combinations of all remaining drugs or, in parallel, of the four most effective compounds (Search 2.2) identified in search 1, were analyzed. Searches 2.1 and 2.2 identified a group of four compounds, which appeared to show the strongest single drug actions, as well as synergistic interactions. A third search was therefore performed to test the interaction of these four compounds in combination. The highlighted pathway corresponds to the final s-FSC technique scheme.
Our Team
Maarten Mennes
Chief Executive Officer
Patrycja Nowak – Sliwinska
Chief Scientific Officer
Yves Kummer
Chief Commercial Officer
Promise of Chimera Bio
1) Acces to library of known compounds
Time / cost efficiency (depending on the test design anywhere from a few days to several weeks)
2) Proprietary technology for creation of optimized compounds / dose combinations
Personalized medicine: we can create combinations for each individual
3) We test in vitro to control efficacy and safety and selectivity
100% guarantee: validated technology in various indications
FACT 1
Complex conditions can not be treated successfully with one compound
FACT 3
Most interventions bases on compound combination were found by “trial and error” approach
FACT 2
Well designed drug combinations may drastically reduce resistance induction and improve tolerability and specificity
CONTACT
info@chimerabio.eu / +31 6 28 59 86 42